Sc. Rep. 15:23044

Bioinformatic analysis finds coronin 3 as a target of microRNA’s dysregulated in medulloblastoma and glioblastoma.

Developmental Cell 60:1–16

BIO-ID identified coronin 3 as an EPLIN (Epithelial protein lost in neoplasm) interactor.

Aging (2024), Vol. 16, 11776-11795

Coronin 3 was one of the proteins found to be upregulated in dermal fibroblasts from old as compared to young subjects.

Cell Biochemistry and Biophysics doi: 10.1007/s12013-024-01591-4

Lu et al. show data suggesting increased coronin 3 expression in ovarian cancer tissue and that coronin 3 depletion inhibited proliferation, migration, and invasion of SKOV3 cells.

Placenta 156 (2024) 67–76

Here, coronin 3 is found to be down regulated in placentas of preeclampsia pregnant women and that to be downregulated in trophoblasts cells leads to reduced migration and proliferation and increased cell death.

Molecules (2024), 29, 4818

In this study several coronin proteins including coronin 3 were detected by proteomics of isolated endocytic vesicles.

Eur J Transl Myol 11555, 2023

Proteomic analysis of brain sections from the wobbler mouse showed elevated levels of coronin 3.

Non-Coding RNA 2023, 9, 4

In this paper a number of databases were analyzed with respect to coronin 3 expression as well as putative miRNA’s potentially targeting coronin 3 expression.

Genes 2023, 14, 995

Analysis of the effect of microRNA expression on coronin 3 expression, cell growth and migration of pancreatic ductal adenocarcinoma cells.

Clin Kidney J (2022) 15:1542-1552

Overexpression of coronin 3 in renal cell carcinoma increases cell proliferation, migration and invasion.

Act Biochim Biophys Sin (2022) 54:673-685

This paper provides a number of assays reporting interaction of P21-activated kinase 4 (PAK4) with coronin 3 using various tagged and recombinantly as well as in vitro expressed proteins.

J Cell Biol (2022) 221:e202111126

Generation and characterisation of a coronin 2/3 double knockout cell line reveals that contrary to previous observations (e.g., Cai et al 2007, PMID: 17350576) excessive cofilin acculmulates in coronin null lamellipodia.

J Cell Biol (2022) 221:e202110089

Re-expression of a HALO-tagged coronin 3 coiled coil domain restores endosomal actin confinement, ER recruitment and endosome fission in coronin 1/2/3-depleted COS-7 cells.

Int J Mol Sci (2021) 21:8155

Platelet activation with laminin results in up regulation of a number of proteins including coronin 3.

Cancer Lett (2021) 516:13-27

This paper shows interaction of tagged RAD23B with HA-tagged coronin 3 when co-expressed in colorectal cancer cell (CRC) lines and that overexpression of HA-tagged coronin 3 enhanced migration, invasion and adhesion capacities of CRC.

Front Mol Biosci (2021) 8:682594

In this work, trophoblast cell surface protein 2 (Trop2) was over expressed in 293T cells and one of the co-eluted proteins was coronin 3, that was also shown to be over expressed in colorectal cancer tissues compared to adjacent tissues.

Technol Cancer Res Treat (2021) 20:1533033821990040

Data are presented showing that miR136-5p targets the 3’UTR of coronin 3 and represses its expression in non-small cell lung cancer cell lines.

Mol Cell Biochem (2020) 470:165-174

Suppression of lnRNA MALAT1 up regulates miR-1-3p and decreases coronin 3 protein expression and in parallel inhibited tumor growth and EMT.

J. Cell Biol. (2021) 220:e202102043

Galloni et al. analyse a role for coronin 3 in the recruitment of the methionine monooxygenase MICAL2, in order to allow oxidation of Arp3b thereby promoting actin disassembly.

Cell Mol Biol Lett (2020) 25:22

miR-206 represses coronin 3 expression and over expression of coronin 3 reverses inhibition of proliferation and migration by iR-206.

Front Oncol (2020) 10:931

Coronin 3 expression is here shown to correlate with tumorigenesis and GSEA/GSVA analysis suggests involvement in EMT transition.

Mol Cell Biochem (2020) 463:137-146

MiR-26, that suppresses renal cell cancer, is shown here to bind to the coronin 3 promoter and downregulate its expression whereas coronin 3 overexpression overcomes miR26-mediated suppression of growth.

Onco Targets Ther (2020) 13:6661-6673

Coronin 3 is over expressed in glioblastoma cells where it increases β-catenin/Wnt signaling, and KD of coronin 3 reduces glioblastoma cell growth, migration and invasion.

Sci Rep (2020) 10:11958

Loss of coronin 3 results in higher tumour burden and metastasis in mouse melanoma, in apparent contrast to data shown in a related study (PMID: 27178841).

Platelets (2019) 31:913-924

Coronin 2 and 3 are shown to form a complex in platelets, localise to membranes in an F-actin-independent manner, and both coronin 1 as well as coronin 2/3 are shown to assemble with Gαs.

Eur J Cell Biol (2019) 98:151046

Here, Solga et al. analyse glioblastoma in the context of coronin 3-deficiency or overexpression.

Oncogene (2018) 37:6425-6441.

Coronin 3 is reported to be upregulated in breast cancer and RNA silencing of coronin 3 inhibited migration.

Cell (2018) 175:254-265.e14

Coronin 3 depletion (siRNA) is here shown to reduce endosome-ER contact sites and fission of FAM21-positive buds with the ER.

Med Sci Monit (2018) 24:5980-5987

Reports high expression of coronin 3 in breast cancer.

BMC Cancer (2017) 17:201

Silencing of the YBX1 transcription factor is shown to inhibit cell migration and invasion and upregulate coronin 3; silencing coronin 3 also reduces migration and invasion in a breast cancer cell line.

Mol Med Rep (2017) 16:3407-3414

This paper describes that coronin 3 is upregulated in hepatocellular carcinoma and modulation of coronin 3 in HepG2 cells regulates the levels of ~250 other proteins, including G6PC3.

Eur J Cell Biol (2016) 95:239-51

Fibroblasts from coronin 3 knockout mice show defects in proliferation, cell migration, and mitochondrial function, in apparent contrast to the results described in PMID: 32686704.

Am J Human Genet (2016) 99:647-665

Coronin 3 is here reported to interact with plastin 3 and coronin 3 overexpression to increase endocytosis in SMN (survival motor neuron)-deficient cells and to reverse axonal truncation and branching in SMN zebrafish.

Nat Cell Biol (2016) 18:76-86

Silencing of coronin 2/3 is reported to increases actin tail lengths in virus-infected HeLa cells.

J Biol Chem (2015) 290:15437-15449

Coronin 3 is reported to be involved in endocytosis of Rac1.

Small GTPases (2015) 6:36-42

This work analyses actin and Rac1 binding properties of coronin 3.

J Human Gener (2015) 60:53-61.

This work reports that microRNA-mediated silencing of coronin 3 in cell lines reduces proliferation and migration.

Mol Oncol (2014) 8:1690-702

miR206 is reported to be down regulated in breast cancer and found to repress coronin 3 expression.

Cancer Biol Ther (2014) 15:1163-73

Coronin 3 is reported to be upregulated in gastric cancer, interact with Arp2 and that overexpression of coronin 3 in MKN28 gastric cancer cells increases motility and migration.

J Cell Sci 1 (2014) 27:4292-307

In this paper an interaction between coronin 2, RCC2 and Rac1 to regulate proper localisation is reported.

Free Radic Biol Med (2014) 67:285-91

Here it is described that coronin 3 co-immunoprecipitates with GST-PTP1B from glioblastoma cells and that silencing coronin 3 suppresses cell growth.

Oncol Rep (2013) 29:1066-72

Here, expression levels of coronin 3 are correlated to cytoskeletal integrity and Rac-1 activation.

Mol. Cell. Bill. (2013) 33:4834-4843

Glucose-induced redistribution of coronin 3 is shown to be inhibited in IQGAP1-silenced cells.

Neuro-Oncology (2013) 15:548–561

Coronin 3 overexpression in glioblastoma cells is shown to increase proliferation and migration/invasion whereas its silencing reduces these events.

Sci. Rep. (2012) 2:241

Here, protein kinase CK2 is shown to phosphorylate coronin 3 at Ser-463 ithat is shown to control in vitro actin bundling and Arp2/3 binding.

Biochem. J. (2012) 444:89–96

In vitro assembly assays using recombinantly expressed coronin 3 fusion proteins showed actin interaction through the unique domain of coronin 3.

Mol. Cancer Molecular Cancer (2012) 11:67

Coronin 3 expression is reported to correlate with metastatic potential of gastric cancer cell lines, and silencing/overexpression to inhibit/increase migration in vitro and mouse models, respectively.

Cell (2010) 143:761-773

Coronin-GFP used as a marker; Unclear which coronin.

Arch. Biochem. Biophys. (2010) 496:33–37

This work links F-actin binding and bundling activity of coronin 3 with Rab27a and endocytosis.

BBRC (2010) 395:318–323

Glucose stimulation of MIN6 cells translocates GFP-coronin 3 to the plasma membrane.

BBRC (2010) 391:394–400

Coronin 3 depletion is reported to increase cell-matrix adhesion and spreading as well as the amount of phosphorylated focal adhesion kinase (FAK) and paxilin.

J Pathol 2010; 222:166–179

Coronin 3 expression was detected to be upregulated in primary effusion lymphoma samples.

J. Exp. Clin. Cancer Res. (2010) 29:17

Coronin 3 is described to be expressed at higher levels in hepatocellular carcinoma cells that show a higher metastatic potential, and coronin 3 expression correlated with disease severity.

J. Mol. Biol. (2009) 393:287–299

This work shows that muscle expresses alternatively spliced coronin 3 forms.

J. Cell Sci. (2008) 121, 3092-3098

Coronin 3 was pulled down using Rab27a affinity chromatography and silencing coronin 3 shown to reduce FM4-64 uptake.

J Pathol (2008) 214:415–424

Here, an analysis of coronin 3 expression in glioblastoma is reported and that shRNA-mediated knockdown of coronin 3 results in reduced cell proliferation, motility and migration without changing F-actin, Arp2/3 or lamellipodia morphology.

Exp. Cell Res. (2007) 313:878-895

Coronin 3 silencing is shown to decrease migration without affecting F-actin. Furthermore, overexpression of EGFP-coronin 3 and its mutants in fibroblasts affect proliferation, cytokinesis and pinocytosis.

Eur. J. of Neurosc. (2005) 21:1155–1168

Here it is reported that coronin 3 is expressed in the central nervous system and over expression of EGFP-coronin 3 fusion proteins affects neurite formation.

J. Biol. Chem (2002) 277:48858–48867

Analysis of coronin 3 domains with respect to F-actin and membrane localisation.

Cytogenet Cell Genet (2000) 88:221–224

Cloning of coronin 3 from a colon cancer cell line library and RNA expression analysis across tissues by Northern blotting.

DNA and Cell Biol (1998) 17:779-787

Okomura et al. describe the cloning of a set of 4 homologous proteins with homology to Dictyostelium coronin, and designate these coronin 1, 2, 3 and 4.