Biopsys. J. (2026) 125:1532–1542

Biophysical characterisation of peptide-based fusion inhibitors based on the coronin 1-defined inhibition of phagosome-lysosome fusion (Ferrari et al (1999), PMID: 10338208), see also PMID: 30385272 and follow up work.

Communications Biology 9:118

Park et al. report synergistic activities of IL-17 and INF-γ in modulating coronin 1 retention on mycobacterial phagosomes. See also PMID: 24497827.

J. Immunol. (2026) 215:vkaf349

Analysis of the promoter and intronic regions regulating coronin 1 expression.

Journal of Neurochemistry (2025)169:e70261

Downregulation of coronin 1 in glioblastoma is shown to be associated with increased tumour aggressiveness.

ESC Heart Failure (2025) 12:3524–3536

Analysis of autoimmune myocarditis in mice lacking coronin 1 expression.

J. Cell Biol. (2025) 224:e202503068

Here, GFP-coronin 1 is shown to associate with the E3 ubiquitin ligase TRIM67 and proposed to function with TRIM67 in neuronal morphogenesis.

Front. Once. 15:10.3389/ onc.2025.1670526

Here, Elihamu et al. analyse databases (TGCA, GTEx) to conclude that high coronin 1 expression correlates with good prognosis and that suppression of coronin 1 expression in breast cancer cells inhibits growth.

The Journal of Neuroscience 45:e1337242025

This works analyses a role for coronin 1 in α synuclein trafficking in the endosomal/lysosomal pathway of microglia.

Circ Arrhythm Electrophysiol. 18:e013217

Mass spectrometry analysis is here used to define biomarkers for sudden cardiac death, including coronin 1.

Biomolecules 15:827

This study in dairy cows proposes that coronin 1 modulates immune responses through phagosome formation.

Redox Biology 82:103618

Here, F-actin disassembly by coronin 1 in neutrophils is proposed to be involved in degranulation, Rac2 modulation and ROS production.

CEN Case Reports, 14:687–692

A human subject with coronin 1-deficiency is described.

Langmuir, 41;26891−26902

Analysis of peptide-based fusion inhibitors based on the coronin 1-defined inhibition of phagosome-lysosome fusion (Ferrari et al (1999), PMID: 10338208), see also PMID: 30385272 and follow up work.

Chem Asian J.

Analysis of the importance of WD repeats in developing peptide-based fusion inhibitors based on the coronin 1-defined inhibition of phagosome-lysosome fusion (Ferrari et al (1999), PMID: 10338208), see also PMID: 30385272 and follow up work.

Veterinary Research (2025) 56:33

Yang et al. report that the activity of coronin 1 in preventing the delivery of pathogenic mycobacteria to lysosomes through Ca2+ signalling is also observed in embryonic bovine lung cells, similar to earlier studies (see PMID: 10338208) and PMID: 17632055).

RSC Med Chem (2025) 16(1):125-136

Further development of peptide-based fusion inhibitors based on the coronin 1-defined inhibition of phagosome-lysosome fusion (see Ferrari et al (1999), PMID: 10338208).

Chemistry (2025) 20;31(11):e202403039.

Sardar et al. follow up on their earlier work (PMID: 33241871) and show data suggesting that coronin 1-based peptides may be useful as broad-spectrum antiviral agents.

Scientific Reports | (2024) 14:31516

Here, using cocultures of T cells and breast cancer cells, Kros et al. analyse modulation of coronin 1 expression and a role in blood brain barrier crossing.

Theranostics (2024) 21;14(18):7023-7041

These authors report on coronin 1 expression and its modulation in MDA-MB-231 (human epithelial cells).

Molecules (2024), 29, 4818

In this study several coronin proteins were detected by proteomics of isolated endocytic vesicles.

Archives of Toxicology (2024) 98(12):4033-4045

This study investigates proteomic profiles of hearts from rats exposed to 2-MCPD, a processing-induced chemical contaminant, and find up regulation of coronin 1.

Life (Basel) (2024) Jul 6;14(7):883

In this work coronin 1 is reported as one of the upregulated proteins in diabetic versus non-diabetic vitreous fluids.

J. Phys. Chem. (2024) 128:20,

In this paper Pandia et al. demonstrate that a coronin 1-derived peptide inhibits membrane fusion irrespective of the cholesterol content of the membrane. See also PMID: 33689373, PMID: 31473192 and PMID: 30385272.

Int J Mol Sci (2024) 9:25, 3145

Following up on earlier work reporting protein kinase C (PKC)-mediated phosphorylation of coronin 1 in the context of mycobacterial survival within macrophages (PMID: 24497827), these authors perform a global analysis of PKC targets that may facilitate mycobacterial infection in macrophages.

Clinical Proteomics (2024) 21:17

This paper analysing proteomic data from breast cancer and reports on upregulation of coronin 1 protein in immune-inflamed tumours.

J Allergy Clin Immunol Glob. (2024) 27;3(1):100172

These authors describe describe a missense mutation in the CORO1A gene and a de novo heterozygous microdeletion of the 16p11.2 chromosome, leading to combined immunodeficiency and underlying defects in cell motility and calcium signalling.

Cell Reports (2023) 42, 112594

While this paper focusses mainly on yeast Crn1, data are shown analysing the localization of GFP-coronin 1 fusion proteins and their mutants in fibroblasts.

GERMS (2023) 13(1):20

This study reports abnormal coronin 1 protein expression in tuberculosis patients.

Front. Mol. Biosci. (2023) 10:1327233

In this study aimed at establishing a salivary proteomic profile which features healthy individuals coronin 1 was one of the six most representative proteins across all subjects.

J Leukoc Biol (2023) 27;114:116-125

Analysis is presented of coronin 1 localization with and without immune complex stimulation in wild type and Rac2-deficient neutrophils.

BBA - Molecular Basis of Disease (2024) 166914

Deng et al. report on the transcriptional repression of coronin 1 by the cAMP-responsive element-binding protein H (CREBH) .

Cell Mol Immunol (2023) 20:941-954

This paper reports on coronin 1 being an interactor and substrate of the wild-type p53-induced phosphatase 1 (Wip1).

Int. J. Mol. Sci. (2023) 24, 4410

Here, Principi et al. describe coronin 1 as the protein with the highest correlation when evaluating the progression of fibrosis.

Sci sign (2022) 15(759):eabo5363

In this work, the authors define a coronin-regulated, evolutionarily conserved mechanism by which cells are informed of and coordinate their relative population size.

J Plant Biol (2022) 65:21-28

In this study the coronin 1 coiled coil domain is used to induce trimerization in order to produce oligomer vaccine candidates, , see also PMID: 16172398.

J Mol Med (2022) 100:1307-1319

In a rat model of neural tube defects, Wang et al. detect differential expression of coronin 1 in serum exosomes associated with spina bifida aperta embryogenesis.

J. Proteomics (2022) 255:104487

In this paper, studying intestinal inflammation in Atlantic salmon, Kiron et al. show that coronin 1 protein levels are increased upon inflammatory diets .

Int Immunopharm. (2022) 109:108804

Min et al. report a correlation between coronin 1 expression and HLA-A*24:02 positive cells treated with carbamazepine.

J. Leuk. Biol. (2022) 112:475-490

This paper shows that in macrophages, the transcription factor Klf10 serves to dampen INF-γ release allowing the survival of M. tuberculosis; in cells lacking Klf10, increased IFN-γ release results in the phosphorylation and macropinosomal relocation of coronin 1 thereby allowing the killing of M. tuberculosis (see also PMID: 24497827).

Front Med (2022) 16:723-735

Exosomal proteins show higher coronin 1 levels in ALS than in controls, correlating with increased apoptosis, autophagy, Ca2+-dependent calcineurin activation and blocking the fuse of autophagosomes with lysosomes.

Sci Sign (2021) 14:eabj0057

This paper reveals a coronin 1–dependent PI3Kδ pathway that is independent of pMHC:TCR and IL-7 signalling and essential for peripheral T cell survival whereas thymus selection and output was found to be normal, in apparent contrast to Shiow et al. (2008), PMID: 18836449.

Exp. There. Med. (2021) 21:633

Here, coronin 1 is one of the proteins that shows deregulated levels in osteoclasts from 1 versus 3 month old guinea pigs.

Indian J Med Res (2021) 154:866-870

This study positively correlates levels of coronin 1 expression in peripheral mononuclear cells with being infected with Mycobacterium tuberculosis.

FASEB Bioadv (2021) 4:254-272

Pandey and colleagues report here that coronin 1 facilitates calcium mobilisation in astrocytes as reported for T cells (see PMID: 18345003) and on HIV-1 Tat-mediated modulation of coronin 1 expression.

Autophagy (2021) 11:3671–3689

Proteomic analysis of lipid droplets from THP-1 cells shows coronin 1 to be present; further, coronin 1 expression was found to be deregulated in atherosclerotic foam cells from mice.

J Extracell Vesicles (2021) 10:e12153

Fei et al. describe here that extracellular vesicles from HEK293 cells contain coronin 1, that upon neddylation induces multi vesicular body degradation in lysosomes, thus reducing the release of extracellular vesicles.

Front Immunol (2021) 12:687044

Saha et al. show here that that infection of bone marrow-derived macrophages with M. tuberculosis H37Rv causes a coronin 1-dependent rise of intracellular cAMP levels at the vicinity of the phagosomes, and that increased cAMP may induce cofilin-mediated F-actin depolymerisation around the mycobacteria-containing phagosome.

J Immune Res Nov (2021) 13:9409777.

Here, Yang et al. show that the Major Outer Membrane Protein (MOM) from Legionella pneumophila increases NOD2 and RIP2 mRNA and protein levels and decreases FOXO1 and coronin 1 in RAW 264.7 cells.

Biochem Biophys. Report (2021) 27:101041

Oku et al. analyse coronin 1 phosphorylation in human phagocytes. See also PMID: 24497827 and PMID: 12132654.

Angew. Chem. Int. Ed. 2021, 60, 6101–6106

Sardar and colleagues describe a coronin 1-derived peptide that inhibits membrane fusion and protects cells from viral infection, see also Ferrari et al. (1999, PMID: 10338208).

Langmuir (2021) 37:3477-3489

Following up on their earlier work (PMID: 30385272 and PMID: 31473192), Pattnaik et al. describe here that the fusion inhibitory effect of the coronin 1-derived peptide, TG-23 (representing a section within one of the WD repeats of coronin 1) depends on the amount of membrane cholesterol in the PEG-mediated asymmetric fusion of SUVs.

Int J Mol Sci (2020) 22:226

Here, analysis of the leukocytes from human subjects suffering from mucopolysaccharidosis type IVA (MPS IVA), a lysosomal storage disease, identified coronin 1 as one of the dysregulated proteins.

Sci Sign (2020) 13:eaau4518

Ambler et al use a coronin 1-GFP fusion protein to analyze Tumor infiltrating lymphocyte (TIL) - tumor cell interactions and report that coronin 1-GFP is retained for prolonged times at their interfaces .

Int J Mol Sci (2020) 21:356

Using mice lacking coronin 1 expression, Riley et al. conclude that coronin 1 is dispensable for most if not all of the platelet phenotypes reported by Stocker et al. 2018, PMID: 30453345 using the same mouse model.

Int J Mol Sci (2020) 21:8155

Using proteomics it is shown that platelet activation results in coronin 1 protein upregulation.

J Biol Chem (2020) 295:13299-13313

Here, in vitro reconstitution of purified proteins is used to conclude that coronin is involved in actin filament bursting. See also Brieher et al (2006, PMID: 17060499, Kueh et al (2008, PMID: 18663144 and Lin et al., (2010, PMID: 20332110).

Immunity (2019) 50:152-165.e8

Here it is shown that coronin 1-deficiency modulates cAMP concentrations to suppress allo-specific T cell responses without compromising pathogen-specific immunity.

Platelets (2019) 31:913-924

Characterisation of coronin 1 in platelets. See also Stocker et al (2018, PMID: 30453345) and Riley..Rivero 2020 above.

Acta Neuropathol Commun (2019) 7:174

Immunodetection of coronin 1 in brain sections from humans with Alzheimer disease.

Biochem. Biophys. Acta Biomembranes (2019) 1861:183056

Following up on Pattnaik 2018 (PMID: 30385272), the authors show here that the inhibitory effect of TG-23, one of the previously described coronin 1-derived peptides, is reversed in cholesterol containing membranes.

Chem Phys Lipids (2018) 217:35-42

This study describes the effects of three coronin 1-derived peptides (representing sections of WD domains) on membrane fusion (see also Ferrari et al. (1999, PMID: 10338208) and show that such peptides reduce the extent of content mixing.

Thomb Haemostat (2018) 118:2098-2111

Using mice lacking coronin 1 expression, Stocker et al. show data to conclude that coronin 1 is involved in agonist-induced actin polymerization and cofilin phosphoregulation and plays a role in platelet biology with impact on spreading, aggregation and thrombosis, opposing data from Riley et al (2020, PMID: 31948107), using the same mouse model.

Elife (2017) 6:e20003

Here the authors report on T cell activation through Notch results in coronin 1 phosphorylation by PKCtheta and that this phosphorylation inactivates coronin 1, allowing actin-based processes to occur.

Sci. Rep. (2017) 7:41710

Ohmae et al. report that coronin 1 expression decreases during in vitro osteoclast differentiation and is involved in bone resorption through regulation of lysosomal trafficking.

Blood (2017) 130:847-858

This paper shows that in polymorphonuclear neutrophils (PMN) coronin 1 interacts with the intern LFA-1 and is responsible for induction of PMN adhesion and related processes.

FEBS Lett (2016) 590:279-87

Liu et al. show that phosphorylation of coronin 1 on Thr418/424 by cyclin-dependent kinase (CDK) 5 activity is responsible for coronin 1-Gαs association and regulation of cAMP production—see also Pareek et al (2010) PMID: 20937706.

J Biol Chem (2016) 291:22086-22092

Using mice in which coronin 1 is specifically deleted in T cells, Siegmund et al. provide support for a T cell-intrinsic role of coronin 1 in immune cell functioning.

Cell Commun Signal (2015) 13:22

Here, Siegmund and coworkers report that coronin 1 interacts with PKCtheta and activates NFkB transactivation.

J Allergy Clin Immunol (2015) 137:879-88.e2

A homozygous mutation disrupting the coiled coil of coronin 1 was found to result in T cell deficiency.

FEBS J (2015) 282:1167-81

This paper shows data suggesting that upon macrophage stimulation, coronin 1 localisation is modulated through phosphorylation-mediated interaction with 14-3-3ζ and receptor of activated C kinase 1 (RACK1).

J Clin Immunol (2015) 35:100-7.

This paper reports a human subject with a mutation in the gene encoding coronin 1 with a chromosome 16p11.2 de novo deletion, with low to absent naive T cells.

Front Microbiol (2015) 6:946

Here, it is shown that macrophage treatment with vitamin D/chenodeoxycholic acid together with retinoic acid reduces coronin 1 expression, and leads to a reduced parasite burden upon Leishmania infection.

Cell Sign (2015) 27:1688-93

Analysing endothelial cells, these authors conclude that coronin 1 functions in TNFα-induced endothelial cell apoptosis.

Indian J Clin Biochem (2015) 30:323-8

Syal et al. report upregulation of coronin 1 expression in people suffering from diabetes.

Mol Biol Cell (2015) 26:2895-912

Here, Ojeda et al. characterise the E26K mutation (Ptcd mouse strain) in cell-based systems.

J Neurosci (2015) 35:3893-902

Here, Suo et al. report that coronin 1 suppresses neuronal branching through modulating NGF-TrkA-PI3K signaling..

PloS Biol (2014) 12:e1001820

This paper defines a role for coronin 1 in cAMP/PKA-mediated neuronal functioning and that coronin 1 deficiency results in loss of excitatory synapses and neurobehavioral disabilities. See also Suo et al., 2014 (PMID: 24270184).

FEBS Lett (2014) 588:3898-905

This paper reports that coronin 1 trimerisation is essential to promote mycobacterial survival within macrophages, to activate calcineurin and shows that macrophage activation that induces serine-phosphorylation on coronin 1 resulted in coronin 1 monomerisation.

PloS Path (2014) 10:e1003879

This paper shows that upon activation, coronin 1 becomes phosphorylated on serine through protein kinase C-mediated activation that as a result reprograms the endocytic pathway towards macropinocytosis for enhanced clearance of internalised cargo.

Nat Neurosci (2014) 17:36-45

Suo et al. provide evidence for a role of coronin 1 in nerve growth factor (NFG)-mediated neuronal survival through modulation of Ca2+/cAMP/PI3kinase signalling-see also PMID: 24667537.

Neurosci Lett (2014) 582:38-42

Here it is reported that overexpression of coronin 1 in PC12 cells negatively effects neurite outgrowth .

Plos One (2014) 9:e103904

Analysing porcine coronin 1, Liu et al. report that coronin 1 inhibits NFkB (in apparent contrast to a report by Fulton et a, 2014, PMID: 24752751)) through down regulation of NFkB.

J Clin Immunol (2014) 34:871-90

Coronin 1-deficient individuals are here reported to posses depleted CD4 T cells and altered B/NK cell populations associated with viral mucocutaneous syndrome.

Eur J Immunol (2014) 44:1662-71

Fulton and colleagues report on the attenuation of murine graft-versus host disease in the absence of coronin 1 and that coronin 1 is important in the activation of the canonical NFkB pathway (in apparent contrast to PMID: 25093672).

Proc. Natl. Acad. Sci. USA (2014) 111:6708-13

Orange and Mace report that coronin 1 is required for natural killer (NK) cell cytotoxic function and that it promotes the deconstruction of F-actin density thus facilitating effective delivery of lytic granules to the immunological synapse.

APMIS (2014) 123:89-91

Following up on Xu et al., 2014 (PMID: 24547769) this report describes cell surface expression of coronin 1 upon T cell activation.

J Drug Target (2014) 22:488-97

This paper reports cell surface expression of coronin 1 on leukocytes using the monoclonal antibody ZCH-2B8a.

Mol Cell Biol (2014) 34:3388-406.

Following up on Castro-Castro et al (2011, PMID: 21873980), Ojeda et al report in this paper that coronin 1 (and 2) through F-actin modulation and myosin II inactivation induce Rac1 translocation to the plasma membrane.

J. Neurochem. (2013) 126:483-492

A candidate antibody target for a mimotope (UH-CIS6) is here shown to represent coronin 1.

J Allergy Clin Immunol (2013) 131:1594-603

This work defines a new clinical entity of a primary immunodeficiency in human subjects with increased susceptibility to EBV-induced lymphoproliferation associated with hypomorphic coronin 1 mutation.

Mol. Immunol. (2013) 53:379– 386

Here it is show that coronin 1 is dispensable for antigen processing and presentation by dendritic cells.

Immunol. Lett. (2013) 153:62– 70

Here, using a concavanin A-induced liver injury model in mice, Siegmund and colleagues report that coronin 1 is dispensable for leukocyte recruitment as well as a number of other leukocyte functions under inflammatory conditions in vivo.

Circ Res. (2012) 110:450-455

This paper reports on the identification of the coronin 1-encoding gene as a differentially expressed transcript in wild-type versus Niemann-Pick type C1 deficient macrophages exposed to acetylated low-density lipoproteins (AcLDL) and modulates endolysosomal delivery.

J. Biol. Chem (2012) 287:42910-42920

Oku et al. report that Ser-2 and Thr-412 are phosphorylated on coronin 1 and that phosphorylation at Thr-412 reduced the binding affinity for actin.

Cell. Microbiol (2012) 14:710–727

Seto et al. report here that in macrophages infected with M. tuberculosis upon coronin 1 silencing autophagy is induced and on a role for coronin 1 in the modulation of autophagosome formation allowing M. tuberculosis survival.

J Biol Chem (2012) 287:21836–21845

In this paper, the authors shows complex formation of coronin 1/2 with ROCK2.

EMBO J (2011) 30, 3913–3927

In this work Castro-Castro et al. analyse a role for coronin 1 in F-actin-mediated Rac1 localisation and activation.

J. Exp. Med. (2011) 208:1777-1787

This paper concludes that coronin 1 plays a role in mast cell degranulation, in apparent contrast to the work by Arandjelovic et al. (2010, PMID: 20643816).

J. Biol. Chem. (2011) 286:43465-43474

This paper correlates Gene Related to Anergy in Lymphocytes (Grail)-mediated degradation of coronin 1 in T cells that have been rendered anergic.

J. Autoimmun. (2011) 37:198e208

Consistent with Siegmund et al (2011, PMID: 21289301), Kaminski et al. find that mice lacking coronin 1 show suppressed symptoms of experimental autoimmune encephalomyelitis (EAE) and provide provide evidence for a role for coronin 1 in regulating Th17 effector function.

J. Immunol. (2011) 186:4039-4050

Mueller et al. show in this work that coronin 1 does not modulate F-actin and that induction of F-actin failed to induce apoptosis; instead, coronin 1 was found to be required for providing prosurvival signals.

J. Immunol. (2011) 186:3452-3461

Siegmund et al. report a crucial role for coronin 1 for the development of murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. see also Kaminski et al, PMID: 21700422.

Proteome Science (2011) 9:70

Here, coronin 1 is identified as a differentially expressed protein upon neutrophil stimulation with cytochalasin B/fMLF, a difference that was not observed in Rac2-deficient cells.

J. Leuk. Biol. (2010) 88:737-745

In apparent contrast to Foeger et al. (2011, PMID: 21844203) this report shows that mast cells from mice lacking coronin 1 are fully functional.

Blood (2010) 116:1942-1950

Halene et al. show in this paper that deletion of serum response factor (Srf) in the megakaryotyte lineage results in the down regulation at the gene expression level of a number of genes, among which the gene encoding coronin 1.

J. Biol. Chem. (2010) 285:6781–6789

Here, Tsujita et at. show that coronin 1 preferentially binds to PI(4,5)P2-containing liposomes and that PI(4,5)P2 antagonizes the ability of coronin 1 to disassemble actin filament branches.

Cell (2010) 140:731-743

In this study, Kumar et al. use coronin 1 as a target to validate their screen for candidates affecting the survival of M. tuberculosis.

J. Exp. Med. (2010) 207:2507-2519

This paper reveals coronin 1 Thr-418 phosphorylation by cyclin dependent kinase (Cdk) 5 and that Cdk5 deletion abrogates T cell activation and attenuates experimental autoimmune encephalomyelitis-see also Liu et al. (2016; PMID: 26823173),

Clin. Exp. Immunol. (2009) 156: 495–501

This work provides evidence for suppression of TLR-mediated signal activation in human macrophages by coronin 1, and that TLR2-mediated activation of the innate immune response resulted in suppression of coronin 1 expression. Furthermore, it is described that M. leprae infection inhibited the TLR-2-mediated coronin 1 suppression and nuclear factor-κB activation.

J. Immunol. (2009) 182:7254-7263

Here, Moriceau et al. show that, as in T cells, expression of coronin 1 in neutrophils negatively correlates with apoptosis.

Clin. Immunol. (2009) 131, 24–30

This work describes a human subject that paired a coronin 1 mutation with a chromosome 16p11.2 deletion in which T cells have disappeared, consistent with previously analysis in mice.

J. Immunol. (2009) 182:2745-2752

Here it is shown that in mice lacking coronin 1 neutrophil populations developed normally, and that coronin 1-deficient neutrophils are fully functional, in apparent contract to the conclusions reached by Yan et al (2007, PMID: 17442961).

J. Immunol. (2009) 182:1954-1961

Combaluzier et al. show here that coronin 1 is essential for intracellular Ca2+ mobilization and proliferation upon triggering of the B cell receptor, while the presence of costimulatory signals renders coronin 1 dispensable for B cell signalling,.

Biol. Pharm. Bull (2008). 31861—865

Here, Hayashi and colleagues show that we show that coronin 1 is excluded from phagosomes containing live L. pneumophila.

J. Cell Biol. (2008) 182:341–353

Following up on previous work (Brieher et al (2006, PMID: 17060499, and see also PMID: 32723865), Kueh et al. show in vitro imagining analysis and conclude that actin disassembly by cofilin, coronin, and Aip1 occurs in bursts. See also the in vivo analysis described by Lin et al., (2010, PMID: 20332110).

J. Mol. Biol. (2008) 376:607–613

Using electron microscopy and in vitro reconstitution Garkin et al. analyze complexes of coronin and actin.

Mol. Biol. Cell (2008) 19, 1241–1251

Analysis of cells in which coronin 1 is stably knocked down suggests a role for coronin 1 in mycobacterial trafficking but not in a number of actin-dependent proceses, including phagocytosis, macropinocytosis, cell locomotion, and regulation of NADPH oxidase activity.

PloS One (2008) 3:e3467

Based on the analysis of mice lacking coronin 1 expression, Mugnier et al. conclude on a role for coronin 1 in T cell receptor signalling.

Immunity (2008) 28:40-51

Haraldsson et al. describe in this paper that in mice, a lupus-suppressive locus is caused by a nonsense mutation in the gene encoding coronin 1.

Nature Immunol. (2008) 9:424-431

Shiow et al. conclude in this study that upon coronin 1 mutation, T cells fail to migrate out of the thymus that is in apparent contrast to the data shown by Mori et al. (2021, PMID: 34932374).

Nature Immunol. (2008) 9:424-431

In this work, Mueller et al. describe that coronin 1 is required for Ca2+-dependent pro-survival signalling thus allowing T cell survival .

Cell (2007) 130:37-50

This paper reports the role for coronin 1 in activating Ca2+-dependent signaling processes in macrophages and reveal a function for calcineurin in the regulation of phagosome-lysosome fusion upon mycobacterial infection.

J. Cell Sci (2007) 120:2796-2806

Deghmane et al. show here that coronin 1 is retained on mycobacterial phagosomes by lipoamide dehydrogenase, resulting in phagosome maturation arrest.

J. Neurosc. (2007) 27:9503–9512

Analysis off the interactive of Mindbomb 1 (Mib1), a protein involved in neuronal morphogenesis and communication, revealed coronin 1 as a major interactor.

J. Histochem. Cytochem. (2007) 55:687-700

This report reports on coronin 1 (as well as another analysed protein, IBA-1) being a marker for microglia.

J. Immunol. (2007) 178:5769-5778

Yan et al. show that transduction of a coronin 1-TAT/His6 fragment in neutrophils leads to inhibition of chemotaxis and a reduction in spreading and adhesion, in apparent contrast to the results from Combaluzier (2009), PMID: 19234169.

PloS Path (2007) 3:e186

Davis et al. report that in activated (INF-γ/LPS) macrophages infected with mycobacteria, coronin 1 knockdown results in increased iNOS recruitment to latex bead phagosomes and does not affect mycobacterial survival.

J. Cell Biol. (2006) 175:315-324

Brieher et al. identify coronin (and Aip) in protein extracts from thymus and based upon in vitro reconstitution experiments conclude that coronin facilitates cofilin-mediated disassembly of Listeria actin comet tails .

Science (2006) 313:839-842

Foeger et al. report here on coronin 1-mediated inhibition of F-actin through an Arp2/3-dependent mechanism thereby modulating chemokine-dependent migration of T cells and T cell viability through the induction of F-actin-dependent apoptosis.

Structure (2006) 14:87–96,

This paper reports the crystal structure of the N-terminal coronin 1 domain, confirming the 7-bladed propeller as predicted by Gatfield et al (2005) (PMID: 15800061).

Cell Research (2006) 16:106-112

This report describes the presence of an actin-binding region at the coronin 1 C-terminus.

Acta Histochem. Cytochem. (2006) 39:107–112

Demonstration that coronin 1 coats the M. leprae phagosome (as is the case for phagosomes harbouring other pathogenic mycobacteria, PMID: 10338208), and that M. leprae downregulates coronin 1 expression.

PNAS (2005) 102:13891-6

Here it is demonstrated that trimerisation of the coronin 1 coiled coil is determined by a distinct conserved structural motif defining a universal molecular determinant for trimer formation and proposed that this may be useful for anti-viral drug development.

Mol. Biol. Cell (2005) 16:3077-87

In this study expression of a coronin 1-GFP/TAT/His6 fragment in macrophages is shown to result in cell detachment and reduction of red blood cell phagocytosis.

Biochem. J. (2005) 287:325-331

Oku and co-authors describe the dimeric nature of coronin 1 in this paper, a finding that is in apparent contrast to the trimer defined in Gatfield et al (2005, PMID: 15800061) and Kammerer et al (PMID: 16172398).

Mol. Biol. Cell (2005) 16:2786-2798

Gatfield et al. predict that the WD region of coronin 1 folds into a 7-bladed propeller, determine that coronin 1 trimerizes through its C-terminal coiled coil domain and and define the regions in coronin 1 that are involved in association to the plasma membrane and cytoskeletal association, respectively.

Int. Immune. (2004) 16:231-240

Nal et al. characterize coronin 1 gene and protein expression in mouse embryonic and adult T lymphocytes.

Cell. micro. (2003) 5:25-40

Zheng and Jones report here that pathogenic H. pylori strains expressing the vacuolating cytotoxin arrest phagosome maturation in association with the retention of coronin 1, similarly to what was observed for M. tuberculosis (Ferrari et al, 1999, PMID: 10338208).

Biol. Pharm. Bull. (2002) 25:837—844

Analysis of phosphorylation of coronin 1 by protein kinase C and the effect of PKC inhibitors on coronin 1 localization

J. Biol. Chem. (2002) 277:17320-17326

Fratti et al. report here that Brefeldin A treatment leads to increased coronin 1 recruitment on latex bed phagosomes.

Cell Microbial. (2001) 3:785-93

Schueller et al. conclude in this paper that coronin 1 does not localise to phagosomal fractions in serum/IFN-γ/LPS-activated activated macrophages

FEBS Letters (2000) 485:147-152

This study identifies a high molecular weight complex including coronin 1, that is solubilized by phosphatidyl inositol-3-phosphate kinase activity in a phox-independent manner.

Science (2000) 288:1647-50

Here it is shown that coronin 1 assembles with macrophage membranes in a cholesterol-dependent manner, and that depletion of cholesterol depletes coronin 1 from the membrane and prevents mycobacterial entry into macrophages.

Blood (1999) 93:3521-3530

The authors show the localization of coronin 1 in neutrophils.

Cell (1999) 97:435-47

This study identifies coronin 1 (also known as TACO, for tryptophan aspartate containing coat protein) as a host factor protecting pathogenic mycobacteria within macrophages.

Mamm. Genome (1999) 10:523–525

Here, Kung and Thomas describe the localisation of the gene encoding corning 1 to chromosome 7.

J. Cell Sci. (1998) 111:2877-2884

Analysis of ActA binding protein from a bovine brain extract identified coronin (coronin 1) as one of the ActA binding proteins .

DNA and Cell Biol (1998) 17:779-787

Okomura et al. describe the cloning of a set of 4 homologous proteins with homology to Dictyostelium coronin, and designate these coronin 1, 2, 3 and 4.

Molecular Immunology (1998) 35:376-491

In this paper Chu and Paul find that one of the genes induced by the cytokine interleukin 4 is coronin 1.

Biochem. J. (1997) 328:105-112

Here, the authors find that the Arp2/3 complex co-purifies with coronin 1 and fails to co-migrate on sucrose gradients.

J. Cell Sci. (1997) 110:3071-3081

While analysing cytosolic pho proteins a 57Kd protein was co-purified, identified as coronin 1 and its localization in neutrophils studied.

FEBS Letters (1995) 364:283-288

Cloning of the gene encoding p57 (coronin 1) based on copurification of a 57 kDa protein with phosphatidylinositol-specific phospholipase C.