Front Cell Infect Microbiol (2024) 23:14:1366563

Novel Plasmodium falciparum coronin gene mutations are described in patients treated with artemisinin in Western Nigeria

Front Epidemiol (2024) 15:4:1279835

This study defines known and novel pfcoronin polymorphisms in malaria parasites from Ghana

Antimicrob Agents Chemother (2023) 18;67(10):e0057723

Stress induction caused down regulation of pfcoronin

Nat Communactions 2022 26;13(1):6353.

Similar to earlier results (see e.g. PMID: 30420498), this study reports that mutations in Pfcoronin convey in vitro growth advantage of parasites harbouring Pfcoronin mutations.

Pharmaceuticals 2021, 14, 351

African isolates of P. falciparum, harbouring mutations in pfcoronin were found to be susceptible to in vitro Methylene Blue treatment

Pharmaceutics 2021, 13(8), 1273

Following up on their 2020 study (PMID: 33045351), the authors here analyse the presence of pfcoronin mutations in African P. falciparum isolates, test susceptibility of strains harbouring pfcoronin mutations for quinoline drug sensitivity and conclude that their data do not allow the potential involvement of mutations in the pfcoronin gene in artemisinin resistance to be discounted

Sci Report 10(1):8907

In their analyzed patient cohort, Diallo et al fail to find any Pfk13 or Pfcoronin mutations associated with artemisinin resistance

Int J Antimicr Agents 56(6):106190

Delandre et al. report that the previously identified Pfcoronin mutations by Demas et al, 2019, that correlate with in vitro generated artemisinin resistance cannot be found among resistant patiens. They identify a fourth mutation (P76S), and fail to find a significant association between in vivo reduced efficacy to artemisinin derivatives and the P76S and conclude that polymorphisms in pfk13 and pfcoronin are not the best predictive markers for artemisinin resistance in Senegal.

PloS Genet 28;16(12):e1009266

In this work, Sharma et al. show data that suggests that Pfcoronin may mediate its effects via the same pathway as pfkelch13, a gene whose mutations are widely associated with artemisia resistance.

PNAS 116(26):12613-12614

In this reply to Velevan et al, 2019, Sharma et al argue that given that the findings reported by Velavan et al. are with artemisinin combination therapy, it may be premature to dismiss the potential that Pfcoronin polymorphisms contribute to artemisinin resistance.

PNAS 116(26):12611-12612

In this comment to Demas et al., Velevan rebut the findings by Demas et al. and report (i) different mutations occurring in Pfcoronin and (ii) that Pfcoronin mutations are not associated with ART resistance.

PNAS 115(50):12799-12804

Demas et al. show that selection for resistance leads to strains carrying mutations in coronin

PloS Biol 16(7):e2005345

Here, Douglas et al. investigate residues in Plasmodium actin involved in motility and mosquito organ penetration. They further report that the defects caused by mutating such residues in actin were rescued by over expression of coronin.

Sci Rep 16;7:40655

Gomez-Diaz et al. investigate gene expression at different stages and find pfcoronin to be expressed at the salivary gland stage

PloS Path 12(7):e1005710

Bane et al. report defective motility and decreased transmission of Plasmodium lacking coronin.

Malar J 14:280

Olshina et al. show that Pfcoronin is expressed late in the asexual lifecycle and associates with the plasma membrane in a PIP2-dependent manner. Further, they analyse the in vitro interaction with rabbit muscle actin using recombinant Pfcoronin fusion proteins expressed in insect cells.

Genome Biol 14(11):R128

Bunnik et al. investigate gene expression at different stages and find pfcoronin to be upregulated at the schizont stage

BMC Genomics 30;12:587

Here, pfcoronin to be upregulated at the schizont stage schizont stage.

Mol Microbial 76(1):12-24

This report describes expression of pfcoronin at the late schizont/merozoit stage.

FEBS Letteres 441(2):251-6

Tardier et al. clone the gene encoding a Plasmodium falciparum coronin-like protein.